Dilip Shah

Scientist & Biochemist in Philadelphia

About

Dr. Dilip Shah is a Philadelphia-based scientist and biochemist whose work spans molecular biology, immunology, and translational biomedical research. Originally from Nepal, his early curiosity about the natural world developed into a career dedicated to understanding complex biological systems and translating discovery into therapeutic insight. Dr. Shah earned his B.Sc. in Chemistry, M.Sc. in Biochemistry, and Ph.D. in Biochemistry, supported by multiple competitive fellowship awards from the governments of Nepal and India. His doctoral research focused on immune regulation in autoimmune disease, examining how oxidative stress and antioxidant systems influence inflammatory signaling, cytokine production, and lymphocyte function in conditions such as systemic lupus erythematosus and rheumatoid arthritis. His work helped clarify the role of intracellular glutathione as a key regulator of immune balance and cellular homeostasis, and was published in leading peer-reviewed journals including Immunobiology, Cellular Immunology, and Immunology Letters. Building on this foundation, Dr. Shah expanded his research into vaccine science and lung biology. He contributed to pioneering work using laser-based vaccine adjuvants to enhance immune responses to influenza antigens, demonstrating that controlled, localized immune activation prior to intradermal vaccination can significantly improve immunogenicity. These studies advanced understanding of pulmonary immune networks and respiratory host defense, with findings reported in journals such as Nature Communications and the Journal of Controlled Release. Currently, Dr. Shah’s research interests center on immunotherapeutic and targeted drug development strategies, including chimeric antigen receptor T-cell (CAR-T) therapies and antibody–drug conjugates (ADCs). His work focuses on identifying novel molecular targets and mechanisms that can enable more precise, effective, and safer treatments for hematologic malignancies and solid tumors.